hydrogen rich saline
In place of H 2 gas hydrogen-rich saline HS may be more suitable for clinical application. S have shown that hydrogen-rich saline HRS has a beneficial effect on sepsis.
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Hydrogen-Rich Saline Attenuates the Inflammatory Response by Suppressing NF-κB p65 TNF-α and HMGB1 and Activating IL-10.
. Hydrogen has been proven to be a novel antioxidant through its selectively reducing of the hydroxyl radical. To obtain a mechanistic insight into the effects of hydrogen-rich saline used here a Western blot analysis of the expression of NF-κB p65 protein in the nucleus Figure 7a and IκBα protein in the cytoplasm Figure. Liver damage ROS accumulation cytokine levels and apoptotic.
In another study of hydrogen in an animal rat model of ischemia-reperfusion injury 9b the superior mesenteric artery of the small intestine was clamped and ischemia maintained for 45 minutes and then reperfusion initiated by the removal of the clamp. H 2 concentration in vivo was detected by hydrogen microelectrode for the first time. The effects of hydrogen-rich saline treatment on the histopathological changes of lungs in rats with intestinal IR were shown in Fig.
The infarction size of hearts the levels of creatinine kinasemusclebrain CKMB and cardiac. Compared with the IR group hydrogen-rich saline administration improved the absolute values of HR SBP DBP and MAP in the IRH 2 group P. Hydrogen-rich saline a portable easily administered and safe means of delivering hydrogen gas can exert organ-protective effects through regulating oxidative stress inflammation and apoptosis.
Hydrogenrich saline was administered twice through intraperitoneal injection at a daily dose of 10 mlkg following the operation in the in vivo model and hydrogenrich medium culture was used for cells instead of normal medium in vitro. Hydrogen-rich saline was freshly prepared each week and was sterilized by g radiation. More importantly a higher concentration of hydrogen can be dissolved into HRS.
We investigated the effects of hydrogen on hepatic ischemia-reperfusion IR and laparoscopic hepatectomy in swine. Hydrogen-rich saline is an alternative form of molecular hydrogen that has been widely used in many studies including metabolic syndrome cerebral hepatic myocardial ischemiareperfusion and liver injuries with obstructive jaundice with beneficial results. The ratio of phospho-NF-κB p65 to total NF-κB p65 was much lower in mice treated with hydrogen-rich saline than in untreated mice.
23 Briefly hydrogen gas was dissolved in normal saline for 6 hours under high pressure 04 MPa by using a custom-designed hydrogen-rich water-producing apparatus. These results indicated that the hydrogen-rich saline might be helpful for the recovery of endocrine function of pancreas and it reduced the severity of graft pancreatitis. The activation of p53 by HRS induce autophagy which inhibits the renal apoptosis.
The rats in hydrogen group received 5 mlkg of hydrogen-rich saline sham and burn controls obtained the same amount of saline and the edaravone group was treated with 9 mgkg of edaravone in saline. Osteoradionecrosis of the jaw is a serious complication following radiotherapy for. Hydrogen-Rich Saline Protects Against Intestinal Ischemia-Reperfusion Injury in Rats.
An aluminum bag was used to store the saturated hydrogen saline under atmospheric pressure at 4C and this. We herein aim to verify its protective effects in experimental models of liver injury. However it is unknown whether these effects involve autophagy induction.
The authors explore the protective role of hydrogen-rich saline HRS on attenuation of acute kidney injury after liver transplantation in a rat liver transplantation model. Animals or BV2-cells received HS and an AMPK. Therefore we tested whether HRS prevents cardiac dysfunction by increasing cardiac energy.
It was ensured that hydrogen-rich saline was maintained at a concentration of more than 06 mmoll. Hydrogen-rich saline HS treatment in neonatal mice has been reported to alleviate brain injury following HI but the mechanisms involved are not known. Only laparotomy was performed in the Sham group.
Twenty-one healthy Bama miniature pigs were randomly divided into the sham group ischemia-reperfusion injury IRI group HRS-5 5 mLkg. In the other four groups an intestinal IRI was performed. Hydrogen-rich saline treatment also significantly decreased mucus index collagen deposition and expression of MUC5AC collagen III and VEGF.
Hydrogen-rich saline administration significantly reduced the amylase and lipase levels in the HPT HS group compared with those in the HPT NS group P 005. 1Morphological study showed after 90 min of intestinal ischemia and 4 h of reperfusion the lung tissues of rats were severely damaged in the saline-treated group with severe edema severe alveolar hemorrhage and extensive. Lactated Ringers solution was given at 6 hours postburn.
Hydrogen-rich saline 5 mLkg was intraperitoneally injected immediately and 6 h post-ischemia. Molecular hydrogen H2 was dissolved in saline under high pressure 06 MPa to a supersaturated level for 2 h. Hydrogen can be dissolved in water up to 08 mM under atmospheric pressure at room temperature and its solubilized form the hydrogen-rich saline HRS is advantageous since it is a safe portable and easily handled approach for delivery.
We designed this study to investigate whether hydrogen-rich saline treatment could improve survival and neurological outcome after cardiac arrest. Normal saline NS HRS lipopolysaccharide LPS and LPS plus HRS. We investigated the relationship between HRS and cell autophagy in a neuropathic pain model generated by chronic constriction injury CCI in SpragueDawley rats.
These effects of hydrogen-rich saline on airway inflammation and. Acute kidney injury AKI is one of the common complications in the immediate. The authors investigated the effects of hydrogen-rich saline solution HRSS on intestinal anastomosis performed after intestinal ischemia reperfusion injury IRI.
The beneficial effects associated with decreased levels of oxidative products as well as the increased levels of antioxidant enzymes and accompanied by the increased activity of glucose. The hydrogen-rich saline was prepared as described previously. Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimers disease by reduction of oxidative stress.
Cardiac function was measured. Significant improvement survival rate and neurological function. Hydrogen-rich saline HRS reportedly reduces allodynia and hyperalgesia in a neuropathic pain model.
In this study we investigated the effect. A modified version of the Rice-Vannucci method for the induction of neonatal HI brain injury was performed on postnatal day 7 mouse pups. Taken together these results indicated that hydrogen-rich saline contributed to the recovery of cardiac function and hemodynamic change and improved the tolerance of hearts against IR.
Four groups of rats received intraperitoneal injections of one of the following solutions. Hydrogen-rich saline HRS has antioxidative anti-inflammatory and anti-apoptotic properties. The lungs were harvested 12 hours postburn for laboratory investigations.
Thirty Wistar albino female rats were randomly divided into five groups.
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